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1

Pyridine bioisosteres of potent GluN2B subunit containing NMDA receptor antagonists with benzo[7]annulene scaffold

Zscherp, Robert, Baumeister, Sören, Schepmann, Dirk, Wünsch, Bernhard

Journal:

European Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 569 KB

english, 2018

2

Chemical Research Writing: A Preparatory Course for Student Capstone Research

Schepmann, Hala G., Hughes, Laura A.

Journal:

Journal of Chemical Education

Year:

2006

Language:

english

File:

PDF, 123 KB

english, 2006

3

Quality and Functionality of Saffron: Quality Control, Species Assortment and Affinity of Extract and Isolated Saffron Compounds to NMDA and σ 1 (Sigma-1) Receptors

Lechtenberg, Matthias, Schepmann, Dirk, Niehues, Michael, Hellenbrand, Nils, Wünsch, Bernhard, Hensel, Andreas

Journal:

Year:

2008

Language:

english

File:

PDF, 264 KB

english, 2008

4

Comparative pharmacological study of common NMDA receptor open channel blockers regarding their affinity and functional activity towards GluN2A- and GluN2B-NMDA receptors

Wünsch, Bernhard, Temme, Louisa, Schepmann, Dirk, Schreiber, Julian A, Frehland, Bastian

Journal:

Year:

2018

Language:

english

File:

PDF, 1.44 MB

english, 2018

5

Exploitation of an additional hydrophobic pocket of σ1 receptors: Late-stage diverse modifications of spirocyclic thiophenes by C–H bond functionalization

Meyer, Christina, Neue, Benedikt, Schepmann, Dirk, Yanagisawa, Shuichi, Yamaguchi, Junichiro, Würthwein, Ernst-Ulrich, Itami, Kenichiro, Wünsch, Bernhard

Journal:

Organic & Biomolecular Chemistry

Year:

2011

Language:

english

File:

PDF, 460 KB

english, 2011

6

Enantiomerically Pure 2-Methyltetrahydro-3-benzazepin-1-ols Selectively Blocking GluN2B Subunit Containing N -Methyl- d -aspartate Receptors

Tewes, Bastian, Frehland, Bastian, Schepmann, Dirk, Robaa, Dina, Uengwetwanit, Tanaporn, Gaube, Friedemann, Winckler, Thomas, Sippl, Wolfgang, Wünsch, Bernhard

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 4.43 MB

english, 2015

7

Benzimidazolone bioisosteres of potent GluN2B selective NMDA receptor antagonists

Lütnant, Ines, Schepmann, Dirk, Wünsch, Bernhard

Journal:

European Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 553 KB

english, 2016

8

Synthesis and pharmacological evaluation of conformationally restricted kappa-opioid receptor agonists

Wuensch, Bernhard, Wenker, Yvonne, Soeberdt, Michael, Daniliuc, Constantin Gabriel, Ständer, Sonja, Schepmann, Dirk

Journal:

Year:

2016

Language:

english

File:

PDF, 829 KB

english, 2016

9

Bioisosteric replacement of central 1,2,4-oxadiazole ring of high affinity CB 2 ligands by regioisomeric 1,3,4-oxadiazole ring

Heimann, Dominik, Lueg, Corinna, de Vries, Henk, Frehland, Bastian, Schepmann, Dirk, Heitman, Laura H., Wünsch, Bernhard

Journal:

Year:

2017

Language:

english

File:

PDF, 597 KB

english, 2017

10

2-Methyltetrahydro-3-benzazepin-1-ols – The missing link in SAR of GluN2B selective NMDA receptor antagonists

Dey, Sougata, Schepmann, Dirk, Wünsch, Bernhard

Journal:

Bioorganic & Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.06 MB

english, 2017

11

Fluorinated GluN2B receptor antagonists with a 3-benzazepine scaffold designed for PET studies

Wünsch, Bernhard, Szermerski, Marina, Börgel, Frederik, Schepmann, Dirk, Betzel, Thomas, Ametamey, Simon, Haider, Ahmed

Journal:

Year:

2018

Language:

english

File:

PDF, 1.77 MB

english, 2018

12

Fluorinated 2-Arylcyclopropan-1-amines â A new class of sigma receptor ligands

Schinor, Benjamin, Hruschka, Svenja, Daniliuc, Constantin G., Schepmann, Dirk, WÃ¼nsch, Bernhard, Haufe, GÃ¼nter

Journal:

Bioorganic & Medicinal Chemistry

Year:

2020

File:

PDF, 1.15 MB

2020

13

Über die Cellulose der Jute

Adolf Lehne, W. Schepmann

Journal:

Angewandte Chemie

Year:

1925

Language:

german

File:

PDF, 832 KB

german, 1925

14

ChemInform Abstract: Enantioselective Synthesis of a 2,2-Disubstituted Tetrahydro-3-benzazepine as Novel NMDA Receptor Antagonist.

Syed Masood Husain, Roland Froehlich, Dirk Schepmann, Bernhard Wuensch

Journal:

Year:

2010

File:

PDF, 25 KB

2010

15

ChemInform Abstract: Asymmetric Synthesis of Enantiomerically Pure 1,4-Di- and 1,1,4-Trisubstituted Tetrahydro-1H-3-benzazepines.

Soumya Sarkar, Dirk Schepmann, Bernhard Wuensch

Journal:

Year:

2012

Language:

english

File:

PDF, 38 KB

english, 2012

16

Enantioselective σ1 receptor binding and biotransformation of the spirocyclic PET tracer 1′-benzyl-3-(3-fluoropropyl)-3H-spiro[[2]benzofuran-1,4′-piperidine]

Christian Wiese, Eva Große Maestrup, Dirk Schepmann, Stefan Grimme, Hans-Ulrich Humpf, Peter Brust, Bernhard Wünsch

Journal:

Year:

2011

Language:

english

File:

PDF, 300 KB

english, 2011

17

Sila-Haloperidol, a Silicon Analogue of the Dopamine (D2) Receptor Antagonist Haloperidol: Synthesis, Pharmacological Properties, and Metabolic Fate

Reinhold Tacke, Friedrich Popp, Barbara Müller, Bastian Theis, Christian Burschka, Alexandra Hamacher, Matthias U. Kassack, Dirk Schepmann, Bernhard Wünsch, Ulrik Jurva, Eric Wellner

Journal:

Year:

2008

Language:

english

File:

PDF, 418 KB

english, 2008

18

Synthesis and Pharmacological Evaluation of SNC80 Analogues with a Bridged Piperazine Ring

Ralph Holl, Bettina Jung, Dirk Schepmann, Hans-Ulrich Humpf, Renate Grünert, Patrick J. Bednarski, Werner Englberger, Bernhard Wünsch

Journal:

Year:

2009

Language:

english

File:

PDF, 375 KB

english, 2009

19

Design, Synthesis, and Biological Evaluation of 3-Benzazepin-1-ols as NR2B-Selective NMDA Receptor Antagonists

Bastian Tewes, Bastian Frehland, Dirk Schepmann, Kai-Uwe Schmidtke, Thomas Winckler, Bernhard Wünsch

Journal:

Year:

2010

Language:

english

File:

PDF, 390 KB

english, 2010

20

Frontiers in Medicinal Chemistry 2010: The Highlights

Dirk Schepmann, Bernhard Wünsch

Journal:

Year:

2010

Language:

english

File:

PDF, 811 KB

english, 2010

21

A 18F-Labeled Fluorobutyl-Substituted Spirocyclic Piperidine Derivative as a Selective Radioligand for PET Imaging of Sigma1 Receptors

Dr. Aurélie Maisonial, Dr. Eva Große Maestrup, Dr. Steffen Fischer, Dr. Achim Hiller, Dr. Matthias Scheunemann, Dr. Christian Wiese, Dr. Dirk Schepmann, Prof. Jörg Steinbach, Dr. Winnie Deuther-Conrad

Journal:

Year:

2011

Language:

english

File:

PDF, 491 KB

english, 2011

22

Asymmetric Synthesis of 1-Substituted Tetrahydro-3-benzazepines as NMDA Receptor Antagonists

Ursula Wirt, Dirk Schepmann, Bernhard Wünsch

Journal:

European Journal of Organic Chemistry

Year:

2007

Language:

english

File:

PDF, 295 KB

english, 2007

23

Synthesis and NMDA Receptor Affinity of Ring and Side Chain Homologues of Dexoxadrol

Michael Sax, Roland Fröhlich, Dirk Schepmann, Bernhard Wünsch

Journal:

European Journal of Organic Chemistry

Year:

2008

Language:

english

File:

PDF, 340 KB

english, 2008

24

Synthesis and biological evaluation of a radioiodinated spiropiperidine ligand as a potential σ1 receptor imaging agent

Rui-Qin Chen, Yan Li, Qiu-Yan Zhang, Hong-Mei Jia, Winnie Deuther-Conrad, Dirk Schepmann, Jörg Steinbach, Peter Brust, Bernhard Wünsch, Bo-Li Liu

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

2010

Language:

english

File:

PDF, 192 KB

english, 2010

25

Synthesis and NMDA-receptor affinity of 4-oxo-dexoxadrol derivatives

Michael Sax, Kirstin Ebert, Dirk Schepmann, Birgit Wibbeling, Bernhard Wünsch

Journal:

Bioorganic & Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 201 KB

english, 2006

26

Synthesis and structure–affinity relationships of novel spirocyclic σ receptor ligands with furopyrazole structure

Torsten Schläger, Dirk Schepmann, Ernst-Ulrich Würthwein, Bernhard Wünsch

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 911 KB

english, 2008

27

Synthesis and pharmacological evaluation of bicyclic SNC80 analogues with separated benzhydryl moiety

Bettina Jung, Werner Englberger, Roland Fröhlich, Dirk Schepmann, Kirstin Lehmkuhl, Bernhard Wünsch

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 357 KB

english, 2008

28

Relationships between the structure of 6-allyl-6,8-diazabicyclo[3.2.2]nonane derivatives and their σ receptor affinity and cytotoxic activity

Ralph Holl, Dirk Schepmann, Renate Grünert, Patrick J. Bednarski, Bernhard Wünsch

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 371 KB

english, 2009

29

Relationships between the structure of 6-substituted 6,8-diazabicyclo[3.2.2]nonan-2-ones and their σ receptor affinity and cytotoxic activity

Ralph Holl, Dirk Schepmann, Patrick J. Bednarski, Renate Grünert, Bernhard Wünsch

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 386 KB

english, 2009

30

Synthesis of spirocyclic σ1 receptor ligands as potential PET radiotracers, structure–affinity relationships and in vitro metabolic stability

Eva Große Maestrup, Christian Wiese, Dirk Schepmann, Achim Hiller, Steffen Fischer, Matthias Scheunemann, Peter Brust, Bernhard Wünsch

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 485 KB

english, 2009

31

Design, synthesis and SAR analysis of novel selective σ1 ligands (Part 2)

Daniela Rossi, Mariangela Urbano, Alice Pedrali, Massimo Serra, Daniele Zampieri, Maria Grazia Mamolo, Christian Laggner, Caterina Zanette, Chiara Florio, Dirk Schepmann, Bernard Wuensch, Ornella Azzo

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 501 KB

english, 2010

32

Synthesis of σ receptor ligands with unsymmetrical spiro connection of the piperidine moiety

Annemarie Jasper, Dirk Schepmann, Kirstin Lehmkuhl, Jose Miguel Vela, Helmut Buschmann, Jörg Holenz, Bernhard Wünsch

Journal:

European Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 294 KB

english, 2009

33

Synthesis of 7,9-diazabicyclo[4.2.2]decanes as conformationally restricted κ receptor agonists: Fine tuning of the dihedral angle of the ethylenediamine pharmacophore

Sunil K. Sunnam, Elisabeth Rack, Dirk Schepmann, Bernhard Wünsch

Journal:

European Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 571 KB

english, 2011

34

Expression of σ receptors of human urinary bladder tumor cells (RT-4 cells) and development of a competitive receptor binding assay for the determination of ligand affinity to human σ2 receptors

Dirk Schepmann, Kirstin Lehmkuhl, Stefanie Brune, Bernhard Wünsch

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2011

Language:

english

File:

PDF, 294 KB

english, 2011

35

Asymmetric synthesis and σ receptor affinity of enantiomerically pure 1,4-disubstituted tetrahydro-1H-3-benzazepines

Syed Masood Husain, Marie Theres Heim, Dirk Schepmann, Bernhard Wünsch

Journal:

Tetrahedron: Asymmetry

Year:

2009

Language:

english

File:

PDF, 595 KB

english, 2009

36

Isolation and identification of 8-hydroxypraziquantel as a metabolite of the antischistosomal drug praziquantel

Dirk Schepmann, Gottfried Blaschke

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2001

Language:

english

File:

PDF, 228 KB

english, 2001

37

Molecular imaging of σ receptors: synthesis and evaluation of the potent σ1selective radioligand [18F]fluspidine

Steffen Fischer, Christian Wiese, Eva Große Maestrup, Achim Hiller, Winnie Deuther-Conrad, Matthias Scheunemann, Dirk Schepmann, Jörg Steinbach, Bernhard Wünsch, Peter Brust

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Year:

2011

Language:

english

File:

PDF, 351 KB

english, 2011

38

Synthesis and NMDA receptor affinity of fluorinated dioxadrol analogues

Ashutosh Banerjee, Dirk Schepmann, Bernhard Wünsch

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 506 KB

english, 2010

39

Synthesis and SAR studies of chiral non-racemic dexoxadrol analogues as uncompetitive NMDA receptor antagonists

Ashutosh Banerjee, Dirk Schepmann, Jens Köhler, Ernst-Ulrich Würthwein, Bernhard Wünsch

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.02 MB

english, 2010

40

Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols

Bastian Tewes, Bastian Frehland, Dirk Schepmann, Kai-Uwe Schmidtke, Thomas Winckler, Bernhard Wünsch

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 2.08 MB

english, 2010

41

Synthesis, pharmacological activity and structure affinity relationships of spirocyclic σ1 receptor ligands with a (2-fluoroethyl) residue in 3-position

Eva Große Maestrup, Christian Wiese, Dirk Schepmann, Peter Brust, Bernhard Wünsch

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 561 KB

english, 2011

42

Design, synthesis and pharmacological evaluation of spirocyclic σ1 receptor ligands with exocyclic amino moiety (increased distance 1)

Elisabeth Rack, Roland Fröhlich, Dirk Schepmann, Bernhard Wünsch

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.15 MB

english, 2011

43

Development of a selective competitive receptor binding assay for the determination of the affinity to NR2B containing NMDA receptors

Dirk Schepmann, Bastian Frehland, Kirstin Lehmkuhl, Bastian Tewes, Bernhard Wünsch

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2010

Language:

english

File:

PDF, 207 KB

english, 2010

44

Separation and identification of zaleplon metabolites in human urine using capillary electrophoresis with laser-induced fluorescence detection and liquid chromatography–mass spectrometry

Christian Horstkötter, Dirk Schepmann, Gottfried Blaschke

Journal:

Journal of Chromatography A

Year:

2003

Language:

english

File:

PDF, 369 KB

english, 2003

45

Synthesis and in vitro Evaluation of Novel Indole-Based Sigma Receptors Ligands

Mine Yarim, Meric Koksal, Dirk Schepmann, Bernard Wünsch

Journal:

Chemical Biology & Drug Design

Year:

2011

Language:

english

File:

PDF, 195 KB

english, 2011

46

Pharmacological and metabolic characterisation of the potent σ1 receptor ligand 1′-benzyl-3-methoxy-3H-spiro[[2]benzofuran-1,4′-piperidine]

Christian Wiese, Eva Große Maestrup, Dirk Schepmann, Jose Miguel Vela, Jörg Holenz, Helmut Buschmann, Bernhard Wünsch

Journal:

Journal of Pharmacy and Pharmacology

Year:

2009

Language:

english

File:

PDF, 296 KB

english, 2009

47

Bivalent β-Carbolines as Potential Multitarget Anti-Alzheimer Agents

Rook, Yvonne, Schmidtke, Kai-Uwe, Gaube, Friedemann, Schepmann, Dirk, Wünsch, Bernhard, Heilmann, Jörg, Lehmann, Jochen, Winckler, Thomas

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 957 KB

english, 2010

48

Synthesis and biological evaluation of conformationally restricted σ1 receptor ligands with 7,9-diazabicyclo[4.2.2]decane scaffold

Sunnam, Sunil K., Schepmann, Dirk, Rack, Elisabeth, Fröhlich, Roland, Korpis, Katharina, Bednarski, Patrick J., Wünsch, Bernhard

Journal:

Organic & Biomolecular Chemistry

Year:

2010

Language:

english

File:

PDF, 777 KB

english, 2010

49

ChemInform Abstract: Microwave Assisted Synthesis of 3-Benzazepine-2-ones as Building Blocks for 2,3-Disubstituted Tetrahydro-3-benzazepines.

Soumya Sarkar, Syed Masood Husain, Dirk Schepmann, Roland Froehlich, Bernhard Wuensch

Journal:

Year:

2012

File:

PDF, 36 KB

2012

50

High-Affinity, Selective σ Ligands of the 1,2,3,4-Tetrahydro-1,4′-silaspiro[naphthalene-1,4′-piperidine] Type: Syntheses, Structures, and Pharmacological Properties

Prof. Dr. Reinhold Tacke, Dr. Rüdiger Bertermann, Dr. Christian Burschka, Steffen Dörrich, Markus Fischer, Dr. Barbara Müller, Géraldine Meyerhans, Dirk Schepmann, Prof. Dr. Bernhard Wünsch, Prof. Dr.

Journal:

Year:

2012

Language:

english

File:

PDF, 532 KB

english, 2012